Doxorubicin hydrochloride鹽酸阿霉素

貨號：MD5142-50mg   350.00

Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride) 是一種有細胞毒性的蒽環類抗生素，常用作腫瘤化療劑。Doxorubicin hydrochloride 抑制拓撲異構酶 II (topoisomerase-II)，從而抑制 DNA 復制。Doxorubicin hydrochloride 下調 AMPK 的基礎磷酸化以及下游 acetyl-CoA 羧化酶。Doxorubicin hydrochloride 誘導凋亡 (apoptosis) 和自噬 (autophagy)

別名: Hydroxydaunorubicin Hydrochloride

Doxorubicin hydrochloride blocks RNA polymerase and reverse transcriptase. It also inhibits nucleic acid synthesis and induces apoptosis.

· Inhibits nucleic Acid synthesis

· Induces apoptosis

· Substrate of MRP1

Naturally fluorescent anthracycline antibiotic, anticancer drug

Doxorubicin Hydrochloride is a chemotherapeutic, antitumor, immunosuppressive, and antibiotic agent.

Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.

Reddish orange powder

Soluble in water (>10 mg/mL), in isotonic sodium chloride, methanol, aqueous alcohols, DMSO (> 10 mg/mL); practically insoluble in chloroform, ether, and other organic solvents.